Capture One
The Topaz Photo AI plug-in automatically installs into Capture One. Access it from:
Image > Edit with > Process with Topaz Photo AI
Capture One will send an image directly to Topaz Photo AI and import the processed image back to Capture One as a copy.
We recommend using unedited RAW files with this plugin.

Image > Edit with > Topaz Photo AI can be used on Windows to round trip the image. However, it cannot create a DNG copy of the image.
DO NOT use Image > Edit with > Topaz Photo AI on Mac. This option does not import the image back to Capture One.